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Altogether; on the whole; primarily; above all
(考虑到一切因素)总的说来,整体看来;主要地;完全
First and last, be sure to be true to your own desires.
说到底,你都要忠于你自己的意愿。
The book is, first and last, an account of a poet's development.
这本书,说到底,就是对一位诗人发展的记述。
千万不要和from first to last记混, from first to last的意思是"从始至终(from start to finish)" 或者是 "贯穿(throughout)"
We cheered them on from first to last.
我们自始至终为他们加油。